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对各型病毒性肝炎患者检测血清Ⅳ型胶原，结果提示：急性黄疸型肝炎血清Ⅳ胶原含量与正常对照组无显著性差异。慢性病毒性肝炎伴早期肝硬化血清Ⅳ型胶原含量明显高于正常值，并随着病程的延长和病情的严重程度而增高。血清Ⅳ型胶原的测定及动态监测对肝纤维化的早期诊断、纤维化的进展和预后的判断具有重要的临床意义。
Serum type IV collagen was detected in patients with various types of viral hepatitis. The results suggested that there was no significant difference in the serum level of collagen Ⅳ between acute jaundice hepatitis and normal controls. Chronic viral hepatitis with early cirrhosis of serum type Ⅳ collagen content was significantly higher than normal, and with the duration of the disease and the severity of the increase. Determination of serum type Ⅳ collagen and dynamic monitoring of liver fibrosis early diagnosis, fibrosis progression and prognosis of the judgment of great clinical significance.