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Objective To study relationship between onset of epilepsy and biological cycle.Method To analyze the incidence of 564 onset of epilepsy in 222 cases for everyday in biological cycle.Result Probability of onset was higher during days between mental state cycle and intelligent cycle,and low point of physical strength.Epilepsy often occurred in high and low point of mental and strength cycle(53.19％ ),30.85％ epilepsy occurred in low point of cycles.Conclusion There is close relation between occurrence of epilepsy and biological cycle.