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心肌梗塞后早期使用巯甲丙脯酸治疗可限制左心室的变型。作者以双盲研究99例心肌梗塞患者(82例男性,年龄范围40～75岁),在心肌梗塞的24小时内随机分配用巯甲丙脯酸或安慰剂治疗,持续1年。巯甲丙脯酸治疗的患者无1例因为急性低血压而停止服药。使用连续切面超声心动图分析心室变型,治疗12个月后左心室舒张末期容量指标(EDVI)在巯甲丙脯酸组增加8.4(1.9)毫升/平方米,安慰剂组19.0(2.6)毫升/平方米,P=0.002;左心室收缩末期容量指标
Early treatment with captopril after myocardial infarction can limit left ventricular variants. The authors studied 99 patients with myocardial infarction (82 males, 40-75 years of age) in a double-blind study and were randomized to either captopril or placebo within 24 hours of myocardial infarction for 1 year. None of the patients treated with captopril stopped taking the drug because of acute hypotension. Using continuous section echocardiographic analysis of ventricular remodeling, left ventricular end-diastolic volume (EDVI) increased by 8.4 (1.9) ml / m 2 in the captopril group and 19.0 (2.6) ml / Square meter, P = 0.002; left ventricular end systolic volume index