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采用改良 Pulsinelli4条血管阻断全脑缺血方法 ,建立血管性痴呆 (VD)大鼠动物模型 ,用 Y型迷宫法定量测定其学习记忆能力 ,计量病理光学显微镜观测其双侧海马 CA1区神经元数目。结果表明 ,治疗组大鼠学习记忆成绩明显优于模型对照组 (P<0 .0 1) ;治疗组双侧海马 CA1区神经元存活数较模型对照组明显增多 (P<0 .0 1)。说明脑力康对 VD大鼠学习和记忆障碍可能有一定的改善作用 ,对其海马神经元可能有一定的保护作用。
The animal models of vascular dementia (VD) were established by modified Pulsinelli 4 vascular block global ischemia methods. The learning and memory abilities were quantified by Y-maze method. The pathological light microscope was used to observe the neurons in both hippocampal CA1 region. number. The results showed that the learning and memory scores of the treatment group were significantly better than that of the model control group (P<0.01). The survival of neurons in the hippocampal CA1 area of the treatment group was significantly higher than that of the model control group (P<0.01). . It was suggested that Naolikang might improve the learning and memory impairment in VD rats, and it may have protective effect on hippocampal neurons.