前列腺癌骨转移模型的早期诊断:DWI及~(99)Tc~m-MDP骨显像比较

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目的比较磁共振(MRI)弥散成像(DWI)及99Tcm-MDP骨显像在裸鼠前列腺癌骨转移模型早期诊断中的应用价值。方法雄性BALB/C裸鼠20只,局部注射法建立前列腺癌骨转移模型。分别在3、7、14、21 d行7.0T MRI T1、T2、DWI扫描和99Tcm-MDP静态骨显像,28 d后为观察终点。随机抽取3只处死后取瘤体作病理HE染色。结果 20只裸鼠中有18只模型建立成功。接种后平均(18.2±0.53)d胫骨周围出现软组织肿块,病理证实为肿瘤组织。造模后(5.5±0.72)d
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