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慢性应激是个体面对特殊环境变化而不能调整和稳定内环境稳态时所经历的持续的情感及心理反应。近年来的研究表明,应激通过神经系统启动瀑布式级联效应,神经内分泌介质修饰肿瘤微环境和应激相关神经内分泌介质激活瘤细胞内增殖和转移相关信号通路,从而影响肿瘤的发生、发展和预后。理解慢性应激在肿瘤演进中的作用和机制,有利于设计合理的干预措施治疗肿瘤。
Chronic stress is the continuous emotional and psychological reaction experienced by an individual in the face of a particular environmental change that can not be adjusted and stabilized. In recent years, studies have shown that stress cascade through the nervous system cascade effect, neuroendocrine medium modification of the tumor microenvironment and stress-related neuroendocrine mediators activate tumor cell proliferation and metastasis-related signaling pathways, which affect the occurrence and development of tumors And prognosis. To understand the role and mechanism of chronic stress in the evolution of the tumor is conducive to the design of reasonable interventions to treat the tumor.