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酒石酸锑钾为广泛沿用的血吸虫病防治药物,我国药典和其他各国药典均有收载,唯含量测定尚存在一些问题,不易掌握。中国药典方法系采用氧化还原方法,在碳酸氢钠存在下直接以碘溶液进行滴定.但因酒石酸锑钾在硷性溶液中极不稳定,生成氢氧化锑,进而成为氧化物白色沉淀,因而在滴定过程中氧化物与碘酸缓缓作用,使终点不明确,同时反应不能定量完成,往往不易得到正确的数据。美国药典,英国药典方法与中国药典方法相同.苏联药典方法系采用溴酸钾溶液氧化破坏指示剂甲红使其红色消失作用
Antimony potassium tartrate is a widely used drug for the prevention and treatment of schistosomiasis. The Chinese Pharmacopoeia and other pharmacopoeias of all countries have been included. However, there are still some problems in the determination of the content, which is not easy to grasp. The method of Chinese Pharmacopoeia adopts the method of redox to directly titrate iodine solution in the presence of sodium bicarbonate, but because of the unstable potassium antimonate tartrate in alkaline solution, antimony hydroxide is generated and becomes the oxide white precipitate, Oxidation of iodine and titration process slow, so that the end is not clear, but the reaction can not be quantitatively completed, often not easy to get the correct data. The United States Pharmacopoeia, the British Pharmacopoeia method and the Chinese Pharmacopoeia the same method. The Soviet Pharmacopoeia method is the use of potassium bromate oxidative damage indicator methyl red red disappear