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目的：探讨代谢综合征及相关指标对 P 波离散度（Pd）的影响，揭示代谢综合征的促心律失常作用。方法选取代谢综合征患者86例，对照组102例，均行12导联同步体表心电图描记，分别测量最大 P 波时限（Pmax）、最小 P 波时限（Pmin）及 Pd。结果与对照组相比，代谢综合征组 Pd 明显增高（47．31±12．18 vs 33．08±11．04， P ＝0．001），但 Pmax 和 Pmin 无明显差异（P ＞0．05）。相关分析显示，Pd 与体质量指数（BMI，P ＝0．001）、总胆固醇（TC，P ＝0．038）、甘油三酯（TG，P ＝0．001）、载脂蛋白 B（Apo B，P ＝0．027）、收缩压（SBP，P ＝0．036）及舒张压（DBP，P ＝0．015）呈正相关性。多元回归分析显示，BMI（P ＝0．001）与 Pd 存在明显的关联性。结论BMI 是影响 Pd 大小的独立危险因素，控制代谢综合征及体质量指数为心律失常防治提供一种新的策略，尤其是心房颤动。“,”Objective To investigate the effect of metabolic syndrome on P wave dispersion (Pd),in order to reveal its proarrhythmic effect.Methods A total of 86 patients with metabolic syndrome and 102 controls were enrolled in the study.The maximum P wave duration (P max)and minimum P wave duration (P min)were measured with 12-lead synchronous surface electrocardiogram (ECG),and Pd was calculated using P max minus P min.Results Com-pared with the controls,patients had significantly higher value of Pd (47.31 ±12.18 vs 33.08 ±11.04,P =0.001). However,there was no much difference in P max and P min between the two groups (P >0.05).Correlation analyses revealed positive correlation between Pd and body mass index (BMI,P =0.001),total cholesterol (TC,P =0.038), triglyceride (TG,P =0.001),apolipoprotein B (Apo B,P =0.027),systolic blood pressure (SBP,P =0.036)and diastolic blood pressure (DBP,P =0.015).Multiple linear regression analysis indicated distinct association between BMI and Pd (P =0.001).Conclusion BMI is an independent influencing factor of Pd.Controlling metabolic syndrome and BMI will provide a new approach for the prevention and treatment of arrhythmia,especially atrial fibrillation.