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目的探讨高血压、体质指数(BMI)与临床术后良性前列腺增生(BPH)的关系。方法采用病例对照研究方法,病例为55～90岁临床诊断为BPH、施行手术治疗、术后病理证实为BPH的患者;对照为同期住院的非前列腺增生患者,年龄与病例相同;病例与对照各380例,以1∶1匹配;采用自行设计的调查表对研究对象进行调查,内容包括一般情况、身体测量、生活方式、既往史以及BPH家族史等,采用Logistic回归模型计算OR值及其相应的95%CI。结果调整年龄因素后,与收缩压正常者(<140 mmHg),(1 mmHg=0.133 3 kPa)相比较,收缩压160～179 mm-Hg者和收缩压≥180 mmHg者发生BPH的危险性明显增加(分别为OR=2.135,95%CI=1.139～4.001和OR=2.704,95%CI=1.475～4.958);高血压病程与BPH呈正相关(χ2=8.876,P=0.031),病程≥20年组发生BPH的危险性明显增加(OR=4.984,95%CI=2.006～12.203,P=0.001)。与非高血压者比较,超重或肥胖者罹患高血压发生BPH的危险性明显地增高(OR=2.548,95%CI=1.397～4.648和OR=2.667,95%CI=1.038～13.212)。结论高血压是BPH发病的危险因素;长期罹患高血压、尤其是高收缩压状态能够促进BPH的发生和发展;超重和肥胖的男性高血压BPH的危险性明显增加。
Objective To investigate the relationship between hypertension, body mass index (BMI) and postoperative benign prostatic hyperplasia (BPH). Methods A case-control study was conducted. The cases were 55 to 90 years old and were clinically diagnosed as BPH. The patients underwent surgical treatment and postoperative pathology were confirmed as BPH. The patients with non-benign prostatic hyperplasia who were hospitalized in the same period had the same age as the cases. 380 cases were matched with 1: 1. The self-designed questionnaire was used to investigate the subjects, including general conditions, body measurements, lifestyle, past history and family history of BPH. Logistic regression model was used to calculate OR and its corresponding Of 95% CI. Results After adjusting for age, the risk of developing BPH was significantly higher in patients with systolic blood pressure of 160 to 179 mm-Hg and systolic blood pressure of ≥180 mm Hg compared with those with normal systolic blood pressure (<140 mm Hg) (1 mmHg = 0.133 3 kPa) (OR = 2.135, 95% CI = 1.139-4.001 and OR = 2.704, 95% CI = 1.475-4.958, respectively). The course of hypertension was positively correlated with BPH (χ2 = 8.876, P = 0.031) There was a significant increase in the risk of BPH in the group (OR = 4.984, 95% CI = 2.006-12.203, P = 0.001). Compared with non-hypertensive subjects, the risk of developing BPH was significantly higher in overweight or obese subjects with hypertension (OR = 2.548, 95% CI = 1.397-4.648 and OR = 2.667, 95% CI = 1.038-13.212). Conclusions Hypertension is a risk factor for BPH. Long-term hypertension, especially high systolic pressure, can promote the occurrence and development of BPH. The risk of BPH in overweight and obese men is significantly increased.