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目的探究HR-HPV的病毒载量对于包括宫颈上皮内瘤变和宫颈癌在内的宫颈病变的预测价值。方法选取该院于2013年1月-2014年12月收治的262例确诊为宫颈病变并接受活检进行病理分析的患者,检测HPV病毒,并根据病理活检结果对患者进行分组,具体分为:宫颈炎症组、CINⅠ期组、CINⅡ~Ⅲ期组、宫颈癌Ⅰ期组和宫颈癌Ⅱ期组。运用HC-Ⅱ检测患者的高危型HPV病毒载量,分析其与病变的关系。结果宫颈炎症组患者的HPV基因载量显著低于CIN患者和宫颈癌患者,宫颈癌Ⅰ期患者的HPV载量远远高于CINⅡ~Ⅲ期组,病毒载量高于100.00时,CIN和宫颈癌的发生率与病毒载量呈正相关,对于宫颈癌Ⅰb~Ⅱ期的患者,病毒载量>100.00时,有更高的出现淋巴结转移及大于4 cm病灶的危险性,但其他特征与病毒载量无关,上述差异均具有统计学意义(P<0.05)。结论高危型HPV病毒载量与宫颈病变联系紧密,较高的HPV病毒载量可对患者构成较大的产生CIN和宫颈癌的风险,且与病灶的临床特征有密切的联系。
Objective To investigate the predictive value of HR-HPV in cervical lesions including cervical intraepithelial neoplasia and cervical cancer. Methods A total of 262 patients diagnosed as cervical lesions who underwent biopsy from January 2013 to December 2014 in our hospital were enrolled in this study. The HPV virus was detected and grouped according to the biopsy results. The patients were divided into cervical Inflammatory group, CINⅠstage, CINⅡ-Ⅲstage, cervical cancerⅠstage and cervical cancerⅡstage. HC-Ⅱ detection of high-risk patients with HPV viral load, analyze the relationship with the lesion. Results The HPV gene load of patients with cervical inflammation was significantly lower than that of patients with CIN and cervical cancer. The HPV load of patients with cervical cancer Ⅰ was much higher than that of patients with CIN Ⅱ ~ Ⅲ. When the viral load was higher than 100.00, The incidence of cancer was positively correlated with the viral load. For patients with stage Ⅰb-Ⅱ cervical cancer, there was a higher risk of lymph node metastasis and lesions larger than 4 cm when the viral load was> 100.00. However, The above differences were statistically significant (P <0.05). Conclusions High-risk HPV infection is closely related to cervical lesions. Higher HPV viral load may cause a greater risk of CIN and cervical cancer in patients, and is closely related to the clinical features of lesions.