Waisbren等应用大剂量氯霉素对95例严重的和暴发性細菌性感染的病人进行治疗。大多数病人在应用大剂量氯霉素前曾用过其它抗菌素治疗。男性58例,女性37例,8例伴有癌肿,4例可能有肝硬变,平均年龄为42岁。70例为严重的葡萄球菌感染,25例为其它細菌之严重感染。初时成人每天氯霉素剂量为8克,溶于500毫升5％葡萄糖液內,95例其平均总量为64克,其中最大剂量是357克,为一多发性脑脓瘍,最小剂量是9克,为一3岁女孩患葡 Waisbren and other large doses of chloramphenicol in 95 cases of severe and fulminant bacterial infections were treated. Most patients have been treated with other antibiotics before using high doses of chloramphenicol. There were 58 males and 37 females with cancer in 8 and cirrhosis in 4, with an average age of 42 years. Seventy patients had severe staphylococcal infection and 25 others were severely infected by other bacteria. At first chloramphenicol daily adult dose of 8 grams, dissolved in 500 ml of 5% glucose solution, 95 cases of its average total of 64 grams, of which the maximum dose is 357 grams, a multiple brain abscess, the minimum dose is 9 grams, for a 3-year-old girl suffering from Portuguese