McKittrick-Wheelock综合征或消耗综合征(depletion syndrome)是以结直肠高分泌性绒毛状腺瘤所导致的大量腹泻、严重电解质紊乱及肾功能异常为主要特点的一种罕见疾病。目前,世界各国报道McKittrick-Wheelock综合征仅60例。近年来,韩国、日本和中国台湾[1]等亚洲地区均有报道,而中国内地尚无相关文献报道。该病于1954年由McKittrick等[2]首先报道,一 McKittrick-Wheelock syndrome or depletion syndrome is a rare disease characterized by large numbers of diarrhea, severe electrolyte disturbances and renal dysfunction caused by colorectal high-grade villous adenoma. At present, all countries in the world reported only 60 cases of McKittrick-Wheelock syndrome. In recent years, South Korea, Japan and China Taiwan [1] and other Asian regions have been reported, but there is no relevant literature in mainland China. The disease was first reported in 1954 by McKittrick et al [2], one