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S100A4蛋白是钙结合蛋白家族成员之一,其通过对钙离子的调节及与靶蛋白的相互作用在体内发挥多种生物学作用,如参与细胞周期活动、细胞分化、肿瘤生长以及细胞外基质分泌活动等过程。近年大量研究表明,S100A4蛋白在多种肿瘤中呈现高表达且具有细胞和组织的分布特异性,并与肿瘤的浸润和转移密切相关,因而备受关注。就S100A4蛋白的分子生物学特点,在调节肿瘤细胞的转移方式和功能方面及其在妇科肿瘤中的作用做文献综述。
The S100A4 protein is a member of the calcium binding protein family that exerts a variety of biological effects in vivo through modulation of calcium ion and its interaction with target proteins such as involvement in cell cycle activity, cell differentiation, tumor growth, and extracellular matrix secretion Activities and other processes. In recent years, a large number of studies have shown that, S100A4 protein in a variety of tumors showed high expression and distribution of cells and tissues with specificity, and tumor invasion and metastasis are closely related, and therefore much attention. The molecular biological characteristics of S100A4 protein in the regulation of tumor cell metastasis and function and its role in gynecologic oncology literature review.