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目的探讨干扰素联合阿德福韦酯对慢性乙肝患者血清干扰素-γ(IFN-γ)/白细胞介素-10(IL-10)的影响。方法 82例慢性乙肝患者随机分为两组,观察组41例,对照组41例,观察组采用干扰素联合阿德福韦酯治疗,对照组采用阿德福韦酯治疗,治疗12月后观察疗效。治疗前后测定血清IFN-γ和IL-10。结果观察组患者的ALT复常率、HBV-DNA阴转率和HbeAg阴转率均高于对照组(P<0.05)。两组治疗后均可升高血清IFN-γ、降低IL-10和升高IFN-γ/IL-10,并且观察组改善上述指标更明显对照组(P<0.05)。结论干扰素联合阿德福韦酯可以通过改善Th1/Th2平衡改善慢性乙肝病情。
Objective To investigate the effects of interferon plus adefovir dipivoxil on the serum levels of interferon-γ (IFN-γ) and interleukin-10 (IL-10) in patients with chronic hepatitis B virus infection. Methods Eighty-two patients with chronic hepatitis B were randomly divided into two groups: 41 in the observation group and 41 in the control group. The observation group was treated with interferon plus adefovir dipivoxil and the control group was treated with adefovir dipivoxil. After 12 months of treatment, Efficacy. Serum levels of IFN-γ and IL-10 were measured before and after treatment. Results The ALT normalization rate, HBV-DNA negative rate and HbeAg negative conversion rate in observation group were higher than those in control group (P <0.05). The levels of IFN-γ, IL-10 and IFN-γ / IL-10 were increased in both groups after treatment, and the above indexes in the observation group were more obvious in the control group (P <0.05). Conclusion Interferon combined with adefovir dipivoxil can improve chronic hepatitis B by improving Th1 / Th2 balance.