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目的 :探讨粘附分子CD4 4 在乳腺癌中的表达及其临床意义。方法 :采用逆转录聚合酶链反应(RT PCR)方法对 30例乳腺癌及 10例乳腺良性肿瘤组织中的CD4 4 基因的表达进行检测。结果 :①CD4 4 V6在乳腺癌中的表达显著性高于乳腺良性肿瘤 ;②乳腺癌组织中CD4 4 V6表达率明显高于CD4 4 S及CD4 4 V3;③Ⅲ、Ⅳ期乳腺癌CD4 4 V6表达显著高于Ⅰ、Ⅱ期乳腺癌 ;④有淋巴结转移的乳腺癌CD4 4 V6的表达明显高于无淋巴结转移者。结论 :CD4 4 V6在乳腺癌中的表达与乳腺癌的发生发展、浸润转移和预后密切相关 ,可作为临床判断浸润转移和估计预后的一个有价值的指标
Objective: To investigate the expression and clinical significance of adhesion molecule CD44 in breast cancer. Methods : The expression of CD4 4 gene in 30 cases of breast cancer and 10 cases of benign breast tumors was detected by reverse transcription polymerase chain reaction (RT PCR). RESULTS: 1 The expression of CD4 4 V6 in breast cancer was significantly higher than that in benign breast tumors; 2 The expression rate of CD4 4 V6 in breast cancer tissue was significantly higher than that of CD4 4 S and CD4 4 V3; and the expression of CD4 4 V6 in breast cancer in stage III and IV. Significantly higher than stage I and II breast cancers;4 The expression of CD4 4 V6 in breast cancer with lymph node metastasis was significantly higher than those without lymph node metastasis. Conclusion: The expression of CD4 4 V6 in breast cancer is closely related to the occurrence, development, infiltration, metastasis and prognosis of breast cancer. It can be used as a valuable index to judge the invasion metastasis and estimate the prognosis.