矽肺是严重危害工人健康的职业病之一。由于矽肺治疗需长期用药,因此,要求药物本身是高效和低毒的。磷酸哌喹(抗矽—14)治疗矽肺虽有一定的疗效,但也有一些毒副作用。为了提高哌喹的生物活性并降低其毒性,上海第二军医大学合成了磷酸羟基哌喹。该药在胃肠道吸收较哌喹快而完全,生物活性高于哌喹,而毒性明显地小于氯喹,对实验性矽肺也有明显的效果,临床试用治疗矽肺 Silicosis is one of the occupational diseases that seriously endanger the health of workers. Due to the long-term use of silicosis treatment, the drug itself is required to be highly effective and less toxic. Piperazine phosphate (anti-silicon-14) Although there is a certain effect of silicosis, but there are some side effects. In order to improve the biological activity of piperacillin and reduce its toxicity, Shanghai Second Military Medical University synthesized hydroxypiperadine. The drug in the gastrointestinal tract than piperaquina absorption faster and more complete biological activity than piperacillin, and toxicity was significantly less than chloroquine, experimental silicosis also have significant effects, clinical trial for the treatment of silicosis