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瘦素已知的作用是调节食物摄入和能量消耗。近年来的研究显示,瘦素参与了肥胖相关的心血管并发症的发病,如高血压和动脉粥样硬化。原发性高血压的患者血浆瘦素升高,排除了体质量影响因素之后,在正常血压和高血压患者中,瘦素和血压之间呈显著正相关。血清瘦素参与了动脉粥样硬化性疾病的发病机制。瘦素在肥胖相关的动脉粥样硬化的病理生理过程中发挥了主要的作用,其病理生理机制是一个相互影响的复杂过程,例如它的促增生作用、促炎性反应、促血栓形成、促氧化应激等作用。
Leptin is known to regulate food intake and energy expenditure. Recent studies have shown that leptin is involved in the pathogenesis of obesity-related cardiovascular complications such as hypertension and atherosclerosis. Plasma leptin levels were elevated in patients with essential hypertension, with a significant positive correlation between leptin and blood pressure in normotensive and hypertensive patients after excluding body mass influencing factors. Serum leptin is involved in the pathogenesis of atherosclerotic disease. Leptin plays a major role in the pathophysiology of obesity-related atherosclerosis. Its pathophysiological mechanism is an interplay of complex processes such as its pro-proliferative effects, proinflammatory responses, pro-thrombosis, pro-inflammatory Oxidative stress and other effects.