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目的:研究血清低密度脂蛋白胆固醇(LDL-C)水平与跟腱厚度(ATT)之间的相关性。方法:2014-03至2015-03期间收集18~75岁、血清LDL-C水平高于正常上限(≥3.37 mmol/L)的患者154例,根据《中国成人血脂异常防治指南(2007年)》,分为LDL-C边缘升高(3.37~4.12 mmol/L)组(n=50)和LDL-C升高(≥4.14 mmol/L)组(n=104);另以血清LDL-C水平正常(<3.37 mmol/L)者作为对照组(n=51)。采用标准化的直接数字化X线摄影术测量三组受试者的ATT,进行比较,并分析血清LDL-C水平与ATT之间的相关性。结果:LDL-C升高组的ATT平均值[(9.42±3.63)mm]高于LDL-C边缘升高组[(8.24±1.73)mm]和对照组[(6.05±0.28)mm],三组受试者ATT间的差异均具有统计学意义(P均<0.05)。线性相关分析显示,血清LDL-C水平与ATT平均值的相关系数r=0.346(P<0.001)。结论:本研究小样本初步观察发现,血清LDL-C水平越高,ATT越厚,血清LDL-C水平与ATT呈正相关,该现象及其意义有待大样本多中心研究进一步证实。
Objective: To study the correlation between serum LDL-C and Achilles tendon thickness (ATT). METHODS: A total of 154 patients aged 18-75 years with serum LDL-C levels higher than the upper limit of normal (≥3.37 mmol / L) were collected from 2014-03 to 2015-03. According to the Guidelines for the Prevention and Treatment of Dyslipidemia in Chinese Adults (2007) (N = 50) and elevated LDL-C (≥4.14 mmol / L) group (n = 104). The serum levels of LDL-C Normal (<3.37 mmol / L) as control group (n = 51). The ATTs of three groups of subjects were measured using standardized direct digital radiography, and the correlation between serum LDL-C levels and ATT was analyzed. Results: The mean ATT in the LDL-C elevated group [(9.42 ± 3.63) mm] was significantly higher than that in the LDL-C elevated group [(8.24 ± 1.73) mm] and the control group [(6.05 ± 0.28) mm] The differences of ATT between the two groups were statistically significant (all P <0.05). Linear correlation analysis showed that the correlation coefficient of serum LDL-C level with ATT average was 0.346 (P <0.001). CONCLUSIONS: The preliminary observation of small sample in this study found that the higher serum LDL-C level, the thicker the ATT and the serum LDL-C level are positively correlated with ATT. This phenomenon and its significance have yet to be confirmed by a large sample of multicenter studies.