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目的观察埃索美拉唑联合左氧氟沙星、阿莫西林克拉维酸钾片14 d疗程治疗幽门螺旋杆菌(helico-bacter pylori,Hp)的临床效果。方法采用随机分组的方法,于2008年5月至2011年6月选择239例Hp感染的患者,随机分为治疗组和对照组。两组均采用埃索美拉唑+左氧氟沙星+阿莫西林克拉维酸钾二联疗法。治疗组为14d疗程;对照组7 d疗程。比较两组疗法Hp根除率及治疗过程中出现的不良反应。结果 164例完成14 d治疗,75例完成7 d治疗。治疗组Hp根除率为91.5%,高于对照组的81.3%,差异有统计学意义(P<0.05)。治疗组不良反应的发生率11.0%,对照组不良反应发生率10.7%,差异无统计学意义(P>0.05)。结论根除Hp三联疗法14 d疗程有效率高于7 d疗程,且不增加不良反应的发生率。
Objective To observe the clinical effect of esomeprazole combined with levofloxacin and amoxicillin-potassium clavulanate for 14 days in the treatment of helicobacter pylori (Hp). Methods A total of 239 patients with Hp infection were selected randomly from May 2008 to June 2011 and were randomly divided into treatment group and control group. Both groups were treated with esomeprazole + levofloxacin + amoxicillin and clavulanate potassium dual therapy. Treatment group for 14d course of treatment; control group 7d course of treatment. Hp eradication rates and adverse reactions during treatment were compared between the two groups. Results 164 cases completed 14 days treatment, 75 cases completed 7 days treatment. The eradication rate of Hp in the treatment group was 91.5%, which was higher than that in the control group (81.3%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the treatment group was 11.0%, while the incidence of adverse reactions in the control group was 10.7%, with no significant difference (P> 0.05). Conclusions The effective rate of eradication of Hp triple therapy for 14 days is higher than that for 7 days without increasing the incidence of adverse reactions.