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以PEG2000-Br为引发剂,甲基丙烯酸甲酯(MMA)为单体,1,6-己二醇二甲基丙烯酸酯(HDMA)为交联剂,采用原子转移自由基聚合(ATRP)制备了两亲交联聚合物PEG-PMMA-HDMA以及作为对照样的线性聚合物PEG-PM-MA。由GPC1、H-NMR研究可知,PEG-PMMA为线性分子,而PEG-PMMA-HDMA为具有交联结构的分子,每个聚合物分子中含有约4.6个线性结构。PEG-PMMA和PEG-PMMA-HDMA以THF为溶剂在水中能够自组装形成包载阿霉素(DOX)的胶团。利用扫描电镜(SEM)和动态光散射(DLS)对胶团的微观结构进行了表征,结果表明胶团粒径小于150nm,粒度分布范围较窄。其中,PEG-PMMA-HDMA胶团的载药量和包封率优于PEG-PMMA,稳定性亦优于PEG-PMMA。
Using atom transfer radical polymerization (ATRP), PEG2000-Br as initiator, methyl methacrylate (MMA) as monomer and 1,6-hexanediol dimethacrylate (HDMA) as crosslinking agent Amphiphilic crosslinked polymer PEG-PMMA-HDMA and linear polymer PEG-PM-MA as a control. By GPC1, H-NMR study shows that PEG-PMMA is a linear molecule, and PEG-PMMA-HDMA is a molecule with a cross-linked structure, each containing about 4.6 linear molecules in the polymer structure. PEG-PMMA and PEG-PMMA-HDMA can self-assemble in water to form micelles containing doxorubicin (DOX) in THF. The microstructure of the micelles was characterized by scanning electron microscopy (SEM) and dynamic light scattering (DLS). The results showed that the size of the micelles is less than 150 nm and the particle size distribution is narrow. Among them, PEG-PMMA-HDMA micelles drug loading and entrapment efficiency than PEG-PMMA, stability is also better than PEG-PMMA.