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目的:探讨肺表面活性物质(珂立苏)治疗新生儿呼吸窘迫综合征(NRDS)的疗效。方法:回顾性分析新生儿诊治中心2008年1月～2009年10月收治的135例NRDS患儿,分析并比较珂立苏使用前,使用后1、6、12 h血气指标、呼吸机参数、胸片变化及并发症发生情况。结果:135例患儿用药前后血气指标及呼吸机参数比较差异有统计学意义,最高吸气末峰压(PIP)、呼气末正压(PEEP)、平均气道压(MAP)及FiO2(吸入氧浓度)在使用珂立苏治疗后均呈下降趋势(P<0.05),NRDS患儿pH及PO2明显升高,PCO2明显降低(P<0.05)。使用珂立苏后发生肺出血4例,占2.36%;气胸6例,占4.24%。结论:珂立苏可明显改善肺的氧合情况,迅速改善新生儿缺氧及酸中毒。
Objective: To investigate the efficacy of pulmonary surfactant (Ke Li Su) in the treatment of neonatal respiratory distress syndrome (NRDS). Methods: A retrospective analysis of 135 neonates with NRDS admitted to the Neonatal Diagnostic and Treatment Center from January 2008 to October 2009 analyzed and compared the blood gas indexes, ventilator parameters, Changes in chest radiography and complications. Results: The blood gas indexes and ventilator parameters in 135 children before and after treatment were significantly different. The peak end-inspiratory pressure (PIP), positive end expiratory pressure (PEEP), mean airway pressure (MAP) and FiO2 ( Inhaled oxygen concentration showed a downward trend (P <0.05) after treatment with triptorelin. The values of pH and PO2 were significantly increased and PCO2 was significantly decreased in NRDS children (P <0.05). Pulmonary hemorrhage occurred in 4 cases, accounting for 2.36%; pneumothorax in 6 cases, accounting for 4.24%. Conclusion: Ke Li Su can significantly improve oxygenation of the lungs, and quickly improve neonatal hypoxia and acidosis.