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目的：观察加味柴胡疏肝散治疗痛性糖尿病周围神经病变的临床疗效。方法：70例痛性糖尿病周围神经病变患者按随机数字表法分为治疗组和对照组，入组后对所有患者用视觉模拟评分法（VAS）对疼痛进行评估。治疗组予以加味柴胡疏肝散治疗，对照组予以盐酸度洛西汀60 mg/d。疗程为1周，治疗结束后比较两组患者治疗效果。结果：VAS疗效比较：与用药前相比，两组患者用药后1，2，3个月VAS均显著下降（P＜0.01），用药后两组间同时间比较，有显著性差异（P＜0.05），治疗组优于对照组（P＜0.05）。结论：加味柴胡疏肝散可有效治疗痛性糖尿病周围神经病变。“,”Objective:To observe the curative effect of modified Chaihu Shugan Powder on diabetic painful neuropathy. Methods:Seventy patients with diabetic painful neuropathy were divided into treatment group and control group by random number table. The pain degree of all patients were evaluated by VAS when they were included in the study. The treatment group was treated by modified Chaihu Shugan Powder and the control group was given duloxetine hydrochloride ,60 mg/d. The treatment course was 1 week. The curative effects of the two groups were compared after treatment. Results:In the first,second and third month after treatment,the scores of VAS of the two groups all significantly decreased (P<0.01). After treatment,there was statistical difference between the curative effects of the two groups (P<0.01). There was significant dif-ference between the two groups (P<0.05). The curative effect of the treatment group was better than that of the control group (P<0.05). Conclusion:Modified Chaihu Shugan Powder can improve the curative effect on diabetic painful neuropathy.