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We have studied the two- and three-photon absorption (2PA and 3PA) properties of Mn-doped CsPbCl 3 two-dimensional nanoplatelets (2D NPs) and cubic nanocrystals. Compared with their cubic counterparts, the Mn-doped 2D NPs exhibit stronger quantum confinement effects that can more efficiently enhance their dopant-carrier exchange interactions and multiphoton absorption. More specifically, the maximum volume-normalized 2PA and 3PA cross sections of the 2D NPs were 6.8 and 7.2 times greater than those of their cubic counterparts, respectively, reaching up to 1237 GM / nm 3 in the visible light band and 2.24 × 10 78 cm 6 · s 2 · photon 2 / nm 3 in the second biological window, respectively.