在温和条件下制备了L-脯氨酸稳定并修饰的负载型金属铱催化剂,用于苯乙酮及其衍生物不对称催化加氢反应.考察了L-脯氨酸的量、溶剂、碱以及碱的量和氢气压力对苯乙酮不对称催化加氢反应的影响.结果显示,该催化剂催化苯乙酮不对称加氢反应获得了92.1%的转化率和32.9%的对映选择性(e.e.),催化2’-(三氟甲基)苯乙醇的对映选择性为39.3%,这一结果高于目前报道的天然手性修饰剂修饰的负载型金属催化剂.该催化循环使用5次,对映选择性只有小幅度下降. L-proline stable and modified supported iridium metal catalysts were prepared under mild conditions for the asymmetric catalytic hydrogenation of acetophenone and its derivatives. The effects of the amount of L-proline, solvent, base As well as the effect of the amount of base and hydrogen pressure on the asymmetric catalytic hydrogenation of acetophenone were investigated.The results showed that the catalyst catalyzed the asymmetric hydrogenation of acetophenone to yield 92.1% conversion and 32.9% enantioselectivity ee), which catalyzed the enantioselectivity of 2 ’- (trifluoromethyl) benzeneethanol was 39.3%, which is higher than that of the currently reported natural chiral modifier-modified supported metal catalysts. , The enantioselectivity decreased only slightly.