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水通道蛋白1(aquaporins1,AQP1)是参与水分子跨膜转运的重要膜通道蛋白家族成员之一,广泛分布于各组织中,在机体物质代谢和水平衡中起着重要的作用。本文就AQP1在哺乳动物各组织中的表达和分布及其参与脑脊液的产生、细胞生物学特性的调节和感觉传导等方面相关功能的研究现况和进展作一综述。
Aquaporins 1 (AQP1) is one of the important membrane channel proteins involved in the transmembrane transport of water molecules. It is widely distributed in various tissues and plays an important role in the metabolism and water balance of the body. This review summarizes the expression and distribution of AQP1 in mammalian tissues and the research status and progress of AQP1 involved in the production of cerebrospinal fluid, the regulation of cell biological characteristics and the sensory transduction.