论文部分内容阅读
近年来,癫痫病人长期用抗惊厥药物治疗时,都以测定血浓度来调整剂量和观察中毒反应,这是癫痫治疗的一大进展。一年来,作者对86例服苯妥因钠(DPH)病人进行了127次血浓度测定。病人绝大多数为原发性癫痫大发作,少数为继发性局限性癫痫。其中52例单独用 DPH,34例合并鲁米那、安定,扑痫酮及利眠宁.DPH 用量大部分为200～300mg/日,平均5.5mg/kg.以改良的紫外分光光度法测定 DPH 浓度.将其中除去因断药及未按医嘱服药
In recent years, epilepsy patients with long-term treatment with anticonvulsant drugs, are to determine the concentration of blood to adjust the dose and observation of toxic reactions, which is a major progress in the treatment of epilepsy. In the past year, the authors performed 127 blood concentrations in 86 patients taking phenytoin sodium (DPH). The vast majority of patients with primary epileptic seizures, a small number of secondary limitations of epilepsy. Among them, 52 cases were treated with DPH alone, and 34 cases were combined with luminal, diazepam, epilepsy ketone and chlordiazepoxide.The most of the dosage of DPH was 200-300mg / day with an average of 5.5mg / kg.Determination of DPH by modified UV spectrophotometry Concentration will be removed due to discontinued and not prescribed medication