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以二甲基肼诱发Wistar大鼠大肠癌为模型,研究了绿茶和茶色素(红茶的主要成分)大肠癌的化学预防作用和对大肠肿瘤的影响。结果表明,在第16周2个饮茶组动物的变性隐窝病灶(ACF)形成数比阳性对照组显著减少(P< 0.01);在第32周时阳性对照组100% 发生了肿瘤(平均瘤数为2.6个/只,平均瘤体积为294.7m m 3/瘤)。绿茶组和茶色素组的平均瘤数抑制率分别为47.1% 和43.1% ,平均瘤体积抑制率分别为77.1% 和68.1% 。表明绿茶和茶色素对实验性大肠肿瘤具有预防作用,ACF作为一个有用的中间终点可代替癌发生率进行大肠癌化学预防剂研究
A model of colorectal cancer induced by dimethyl hydrazine in Wistar rats was used to study the chemopreventive effect of green tea and tea pigment (the main component of black tea) on colorectal cancer and its effect on colorectal tumors. The results showed that at the 16th week, the number of denatured crypt foci (ACF) formation in the 2 tea drinking groups was significantly lower than that of the positive control group (P<0.01); at the 32nd week, 100% of the positive control group had tumors (average The number of tumors was 2.6 per mouse, and the average tumor volume was 294.7 mm 3/tumor). The average tumor inhibition rates of the green tea group and the tea pigment group were 47.1% and 43.1%, respectively, and the average tumor volume inhibition rates were 77.1% and 68.1%, respectively. Shows that green tea and tea pigments have preventive effects on experimental colorectal tumors, and ACF is a useful intermediate endpoint to replace colorectal cancer chemopreventive agents.