论文部分内容阅读
目前全世界老年人高血压病的患病率急剧增高,在俄罗斯高达75%～80%。单纯收缩期高血压(ISAH)是老年人高血压病的主要类型,其发病率每10年增加20%以上。主动脉弹性下降能导致收缩压增高,舒张压下降和脉压增大。在老年人ISAH 时收缩压增高和舒张压降低能促使发生血管内皮损伤、弹力膜破裂、动脉壁破坏、左心室肥厚、左心功能不全和心内膜下灌注不足。已经确定,ISAH 是冠心病,脑卒中和其他心血管合并症的重要危险因素。
At present, the prevalence of hypertension among the elderly in the world has risen sharply, reaching as high as 75% to 80% in Russia. Isolated systolic hypertension (ISAH) is the major type of hypertension in the elderly and its incidence increases by more than 20% every 10 years. Reduced aortic elasticity can lead to increased systolic blood pressure, diastolic blood pressure and pulse pressure increases. Increased systolic blood pressure and decreased diastolic blood pressure during ISAH in the elderly can contribute to vascular endothelial damage, rupture of the elastic membrane, destruction of the arterial wall, left ventricular hypertrophy, left ventricular dysfunction, and inadequate sub-subintimal perfusion. ISAH has been identified as an important risk factor for coronary heart disease, stroke and other cardiovascular comorbidities.