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目的观察乌拉地尔对术中高血压的控制疗效。方法对108例高血压手术病人,在麻醉中将乌拉地尔注射液25mg加入生理盐水10ml缓慢静脉推注,再给予乌拉地尔100mg加入生理盐水250ml中,根据血压水平调整注入速度,最大剂量为10μg(/kg·min),观察收缩压(SBP)、舒张压(DBP)、心率(HR)变化。结果用药后60min,DBP下降≥10mmHg,并降至正常,或虽未达到正常,但下降≥20mmHg,降压显效率75.0%;DBP虽未下降≥10mmHg,但降至正常,或下降10～20mmHg,有效率13.8%,总有效率88.8%,而心率无明显变化。结论乌拉地尔是一种控制术中高血压有效的,起效快,对防止高血压危相以及维持心功能稳定良好的降压药。
Objective To observe the curative effect of urapidil on intraoperative hypertension. Methods A total of 108 hypertensive patients undergoing anesthesia were treated with intravenous injection of 25 mg of urapidil into 10 ml of normal saline and then intravenous injection of 100 mg of urapidil into 250 ml of normal saline. The infusion rate was adjusted according to the blood pressure level. The maximum dose was 10μg / kg · min. The changes of systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were observed. Results After 60min, DBP decreased ≥10mmHg and decreased to normal or not reached the normal level, but decreased ≥20mmHg, the effective rate of antihypertensive effect was 75.0%. DBP did not drop ≥10mmHg, but dropped to normal or decreased 10 ~ 20mmHg , The effective rate of 13.8%, the total effective rate of 88.8%, while no significant changes in heart rate. Conclusion Urapidil is an antihypertensive drug that is effective in controlling intraoperative hypertension, has rapid onset of action, is good for preventing endangering of blood pressure and maintaining cardiac function.