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目的:探讨纳美芬联合盐酸羟考酮对上腹部手术患者麻醉苏醒期躁动的影响。方法:上腹部手术患者随机分为盐酸羟考酮组(A组),纳美芬联合盐酸羟考酮组(B组),术后用P C A镇痛,记录麻醉诱导前、术后1、6、12、24、48h的H R、S P O2、SBP/DBP、躁动发生率、Ramsay评分及疼痛视觉模拟评分(VAS)情况。结果:B组患者Ramsay评分较A组高(P<0.05)、躁动发生率、恶心呕吐发生率、和V A S评分和较A组低(P<0.05)。结论:纳美芬联合盐酸羟考酮用于上腹部手术后镇痛可减少麻醉苏醒期躁动发生率,减少胃肠道不良反应发生。“,”ObjectiveTo investigate the effects of oxycodone hydrochloride and nalmefene on emergence agitation and Hemodynamics of patients undergoing upper abdominal operation.MethodsASA gradeⅠ-Ⅱ patients undergoing elective upper abdominal operation were randomly divided into two groups: oxycodone hydrochloride group (group A), nalmefene and oxycodone hydrochloride group (group B) with 30 patients in each group, after the operation, the incidence of agitation, SBP/DBP, HR, SPO2,VAS score and Ramsay sedation score were recorded at the following time points: before induction of anesthesia, 1, 6, 12, 24, 48 hours after operation.ResultsCompared with group B, Ramsay sedation scores of patients in group A were slightly lower (P<0.05); the incidence and degree of agitation in B group were lower than A group (P<0.01).ConclusionOxycodone hydrochloride combined with nalmefene can make patients quiet cooperation and reduce emergence agitation during recovery period after upper abdominal operation.