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本文在描述血管再狭窄的病理学和细胞学机制的基础上,将抑制血管再狭窄的目的基因分为抗增殖基因、抗迁移基因和多效基因并系统总结了近十年来的研究结果,并对载体选择及输送方法进行了回顾,同时指出了基因治疗在此领域存在的问题及发展方向。
Based on the pathological and cytological mechanisms of vascular restenosis, the purpose of this study is to classify the target genes that inhibit vascular restenosis into antiproliferative genes, anti-migratory genes and pleiotropic genes and systematically summarize the results of the past ten years The carrier selection and delivery methods were reviewed, and the problems and development directions of gene therapy in this field were pointed out.