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目的 探讨载脂蛋白E基因多态性与脑白质疏松症的关系。方法 采用聚合酶链反应 -限制片段长度多态性对 5 0例脑白质疏松症患者和 10 8例正常对照者载脂蛋白E基因型进行分析。结果 脑白质疏松症患者ApoE2等位基因频率为 0 .15 ,明显高于对照组的 0 .0 74 (P <0 .0 5 ) ;在脑白质疏松症患者中检测出携带有Apoε2 /2纯合子基因者 4例 ,携带有Apoε 4 /4纯合子基因者 2例 ,高于对照组。 结论 载脂蛋白E2等位基因 ,尤其是ε 2 /2纯合子基因可能是脑白质疏松症的一种遗传易感因子。
Objective To investigate the relationship between apolipoprotein E polymorphism and leukoaraiosis. Methods Polymerase chain reaction-restriction fragment length polymorphism was used to analyze the apolipoprotein E genotypes in 50 cases of leukoaraiosis and 108 normal controls. Results The allele frequency of ApoE2 in patients with leukoaraiosis was 0.15, which was significantly higher than that in the control group (P <0.05). Apoε2 / 2 was detected in patients with leukoaraiosis 4 cases of zygotic gene, 2 cases carrying Apoε 4/4 homozygote gene, higher than the control group. Conclusion The apolipoprotein E2 allele, especially the ε 2/2 homozygote, may be a genetic predisposition to leukoaraiosis.