目的以盐酸小檗碱为溶出指标,对不同粉碎度中药材制得的万应胶囊在人工胃液中进行溶出量测定,探讨中药材不同粉碎程度对其溶出量的影响。方法以不同粉碎度的中药材药粉制备万应胶囊样品,以盐酸小檗碱含量为测定指标,以浆法测定药物在人工胃液内45min的溶出量。结果不同粉碎度中药材制得的万应胶囊样品在人工胃液内溶出量没有显著差异。结论在制剂过程中万应胶囊中药材粉碎无需过细,以50～100目为宜。 Objective To use berberine hydrochloride as the dissolution index to measure the dissolution of Wan Ying capsules prepared from Chinese herbal medicines with different grinding degrees in artificial gastric juice, and to investigate the effect of different degree of comminution of Chinese herbal medicines on its dissolution. Methods The Wanying capsule samples were prepared with different grinding degree of Chinese herbal medicine powder. The content of berberine hydrochloride was used as the determination index, and the dissolution amount of the drug in artificial gastric juice was measured by the pulp method for 45 minutes. Results There was no significant difference in the amount of Wanying capsules in the artificial gastric juice with different grinding degree of Chinese herbal medicines. Conclusion The Wanyin capsule Chinese herbal medicines should not be crushed during the preparation process, and 50 to 100 mesh is appropriate.