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雄性Ｗｉｓｔａｒ大鼠分别饲以低硒低ＶＥ、适硒低ＶＥ和适硒适ＶＥ３种半合成饲料，４周后每组处死４只大鼠，剩余大鼠半数从第５周起用２０ｍｇ／（ｋｇ·ｄ）串珠镰刀菌素（ＭＦ）灌胃，半数用去离子水灌胃对照，７周后，处死全部大鼠，测睾丸ＰＨＧＰＸ活力及睾丸、血浆和ＲＢＣ硒水平，ＧＰＸ活力。结果表明：给毒前睾丸ＰＨＧＰＸ活力与睾丸、血浆和ＲＢＣ硒水平及ＧＰＸ活力有很好的线性相关，但低硒时ＰＨＧＰＸ并未出现象ＧＰＸ那样明显的下降，表明在睾丸中ＰＨＧＰＸ比ＧＰＸ有更重要的生物学活性。给毒后睾丸ＰＨＧＰＸ活力在３个处理组均出现明显降低，Ｓｅ和ＶＥ并未显示出保护作用，说明ＰＨＧＰＸ是新发现的ＭＦ的另一毒性作用点
Male Wistar rats were fed with semi-synthetic feed with low selenium, low VE, low selenium and low selenium, respectively. After 4 weeks, 4 rats were sacrificed in each group, and the remaining rats were treated with 20 mg / kg · D) Fusarium moniliforme (MF) administered intragastrically, and half of them were treated with deionized water. After 7 weeks, all the rats were sacrificed and testicular PHGPX activity and testicular, plasma and RBC selenium levels and GPX activity were measured. The results showed that there was a good linear correlation between PHGPX activity before testis and testicular, plasma and RBC selenium levels and GPX activity, but PHGPX did not decrease as obviously as GPX during low selenium test, indicating that PHGPX in testes was higher than GPX More important biological activity. The PHGPX activity in testis after administration showed a significant decrease in the three treatment groups, Se and VE did not show a protective effect, indicating that PHGPX is another virulence point of newly discovered MF