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以３％牛磺胆酸钠经胆胰管逆行注射制成大鼠急性出血坏死性胰腺炎（ＡＨＮＰ），并用丹参进行实验性治疗，发现对照组６ｈ出现严重的胰腺出血坏死及微血管破坏，血清胰酶活性显著升高（Ｐ＜０．００１），１２ｈ后血清胰酶活性呈进行性降低，胰腺微血管及组织病变进行性加重；丹参组２４ｈ胰腺微血管损害及组织学病变改善显著（Ｐ＜０．０１）。结果提示：微循环障碍是加重ＡＨＮＰ后期胰腺病变的重要因素，丹参能改变胰腺的微循环对ＡＨＮＰ有一定治疗作用。
Acute hemorrhagic necrotizing pancreatitis (AHNP) was induced by retrograde injection of 3% sodium taurocholate into the biliary and pancreatic ducts, and the experimental treatment with Salvia miltiorrhiza was performed. It was found that the control group had severe pancreas hemorrhage, necrosis and microvascular destruction at 6h, (P <0.001). After 12h, the activity of pancreatic enzyme decreased progressively, and the pancreas microvascular and histopathological changes were aggravated. The microvascular damage and histological changes of pancreatic tissue in 24h after Salvia miltiorrhiza were significantly improved (P <0. 01) .01). The results suggest that: microcirculation disturbance is an important factor in aggravating AHNP late pancreatic lesions, Salvia can change the pancreas microcirculation of AHNP have a therapeutic effect.