顽固性高血压在临床实践中并不少见,且由于血压长期得不到有效控制,其心血管风险则更大。顽固性高血压的致病因素众多,发病机制仍不清楚,因此,尚缺乏有效的针对性治疗措施。临床实践中,尽管噻嗪类利尿剂对顽固性高血压疗效不佳,但醛固酮受体拮抗剂却能较好地使其血压得到控制。 Refractory hypertension is not uncommon in clinical practice, and cardiovascular risk is greater due to long-term inability to effectively control blood pressure. There are many pathogenic factors of refractory hypertension, the pathogenesis is still not clear, therefore, there is a lack of effective targeted treatment. In clinical practice, although thiazide diuretics are ineffective in patients with refractory hypertension, aldosterone receptor antagonists can better control their blood pressure.