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目的探讨脂蛋白a在心脑血管病中的临床应用价值。方法用免疫透射比浊法测定200名正常人、100名冠心病、50名脑梗死、50名脑动脉硬化、30名脑出血病人空腹血清中脂蛋白a含量。结果冠心病、脑梗死、脑动脉硬化血清中脂蛋白a明显高于对照组(正常人),脑出血患者血清中脂蛋白增高与出血原因有关。其中冠心病、脑梗死、脑动脉硬化血清中脂蛋白a的增高有非常显著差异变化(P<0.01)而脑出血患者血清中脂蛋白增高无显著差异变化(P>0.05)。结论脂蛋白a是心脑血管病的重要危险因子,测定并全面认识脂蛋白a对临床上预防、诊断心脑血管疾病有着重要的意义。
Objective To investigate the clinical value of lipoprotein a in cardio-cerebrovascular diseases. Methods Immuno-turbidimetry was used to determine the level of serum lipoprotein-a in 200 normal subjects, 100 coronary heart disease patients, 50 cerebral infarcts, 50 cerebral arteriosclerosis patients and 30 cerebral hemorrhage patients. Results Coronary heart disease, cerebral infarction, cerebral arteriosclerosis serum lipoprotein a was significantly higher than the control group (normal), elevated serum lipoprotein in patients with intracerebral hemorrhage and bleeding causes. There was a significant difference in the increase of serum lipoprotein a in patients with coronary heart disease, cerebral infarction and cerebral arteriosclerosis (P <0.01), but there was no significant difference in serum lipoprotein between patients with cerebral hemorrhage (P> 0.05). Conclusion Lipoprotein a is an important risk factor for cardiovascular and cerebrovascular diseases. To measure and fully understand lipoprotein a is of great significance in the prevention and diagnosis of cardiovascular and cerebrovascular diseases.