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采用免疫组织化学法染色,标记基底膜的特异性成分Ⅳ型胶原、层粘连蛋白对宫颈鳞状上皮不典型增生、原位癌,早浸癌及浸润癌的基底膜变化进行观察研究。结果显示正常及不典型增生情况下基底膜是完整,连续的。原位癌基底膜通常是连续的,偶有中断。早浸癌基底膜通常是断续的,偶尔癌巢周围可出现完整、连续的基底膜。浸润癌基底膜的表现与细胞分化有关,分化好的癌巢周围存在基底膜,分化差的则缺少基底膜。基底膜变化的机理可能在于合成和分解代谢的不平衡。
Immunohistochemical staining, labeling of basement membrane specific components of type Ⅳ collagen, laminin on cervical squamous cell atypical hyperplasia, carcinoma in situ, early and invasive carcinoma of the basement membrane changes were observed and studied. The results show normal and dysplastic basal lamina is complete, continuous. In situ carcinoma of the basement membrane is usually continuous, occasionally interrupted. Early-basilar carcinoma of the basal membrane is usually intermittent, and occasionally there may be a complete and continuous basement membrane of cancer. The performance of invasive carcinoma of the basement membrane and cell differentiation, differentiated cancer nest around the presence of basement membrane, poorly differentiated is the lack of basement membrane. The mechanism of basement membrane changes may lie in the imbalance of synthesis and catabolism.