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梔子煎剂和醇提取物对麻醉或不麻醉动物(猫、兔、大白鼠),不论口服或腹腔注射,均有持久性降压作用。静脉注射迅速降压而维持时短。梔子的降压作用与肾上腺素及胆碱生化反应系统,神经节阻断,组织胺的释放均无关系。静脉注射普鲁卡因对梔子的降压作用无影响,但切断迷走神经后,则作用减弱或消除。注射阿托品亦可取消其降压作用,其作用部位似在延脑副交感中枢,梔子醇提取液对家兔及大白鼠离体肠管平滑肌,低浓度(2.5×10~(-4))兴奋,高浓度(2×10~(-2))则抑制,小白鼠急性腹腔注射,LD_(50)为27.45克/公斤。
Gardenia decoction and alcohol extract on anesthetized or non-anesthetized animals (cats, rabbits, rats), regardless of oral or intraperitoneal injection, have a lasting antihypertensive effect. Intravenous injection of rapid decompression while maintaining short. Antihypertensive effect of gardenia and epinephrine and choline biochemical reaction system, ganglion block, histamine release were not related. Intravenous procaine has no effect on the antihypertensive effect of Gardenia, but after the vagus nerve is cut off, the effect is weakened or eliminated. Injection of atropine can also be canceled its antihypertensive effect, its role in the site of the sympathetic to the brain center, Gardenia alcohol extract of isolated white rabbit and rat intestinal smooth muscle, low concentration (2.5 × 10 -4) excited, High concentration (2 × 10 ~ (-2)) inhibited the acute intraperitoneal injection in mice. The LD_ (50) was 27.45 g / kg.