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非整倍体是指染色体数目只有一条或少数几条增减的异常核型 ,主要是由于在生殖细胞发生过程中 ,减数分裂染色体不分离 ,异常配子受精后形成。另外 ,受精卵在有丝分裂过程中染色体不分离亦可形成非整倍体 ,它是导致智力低下、性别异常、自发流产、多发畸形和染色体病的主要原因[
Aneuploidy refers to the number of chromosomes with only one or a few abnormal karyotypes, mainly due to the process of germ cells, meiosis chromosomes do not separate, the formation of abnormal gametes after fertilization. In addition, the zygotes in the process of mitosis during chromosome separation can also form aneuploidy, which is the leading cause of mental retardation, abnormal sex, spontaneous abortion, multiple malformations and chromosomal diseases [