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111例正常早孕人工流产的胎盘组织作绒毛蜕膜组织化学观察。蜕膜细胞,富于糖元,碱性磷酸酶多呈阳性或弱阳性,酸性磷酸酶多数阴性或弱阳性,少数阳性。3β-HSD弱阳性,蜕膜腺体弯曲呈锯齿状,腺体壁呈扇形,有时细胞向内突出如鞋钉状,腔内充满分泌物,糖元强阳性,对维持早期妊娠是一个重要营养条件。早期妊娠绒毛具有完整两层滋养层,即合体滋养层及细胞滋养层,60天后则细胞滋养层逐步消失,绒毛大小不等,胎儿血管扩大并移向绒毛表面,从而使胎儿-母体胎盘屏障变薄,有利于胎儿-母体的物质交换,是适应胚胎发育的一个重要条件。早孕期绒毛组织化学检查显示绒毛两层细胞糖元和碱性磷酸酶活性都很强,反映代谢机能活跃,细胞滋养层胞浆酸性磷酸酶活性60—90天逐渐加强,这应与此时期细胞滋养层退化有关。3β-HSD 在甾体生物合成过程中起重要作用,绒毛滋养层细胞3β-HSD皆为阳性,表明具有甾体生物合成机能。着床、早孕过程中,绒毛、蜕膜是母体-胚胎直接接触和相互联系的两种组织,从计划生育角度,在发展抗着床、抗早孕药物研究工作中,对于蜕膜、绒毛形态和机能的研究应当受到重视。
111 cases of normal early pregnancy abortion placental tissue for chorionic decidual tissue chemistry. Decidual cells, rich in glycogen, alkaline phosphatase mostly positive or weak positive, acid phosphatase most negative or weak positive, a few positive. 3β-HSD weakly positive, deciduous glands curved serrated, glandular wall fan-shaped, and sometimes protruding inwardly like cells like spikes, the cavity is full of secretions, glycogen strong positive, to maintain early pregnancy is an important nutrition condition. Early pregnancy has two layers of trophoblast trophoblast, that is, syncytiotrophoblast and trophoblast layer, 60 days after the trophoblast layer gradually disappear, villus size, fetal blood vessels and move to the villus surface, so that the fetus - maternal placental barrier change Thin, conducive to fetal - maternal material exchange, is an important condition to adapt to embryonic development. Histochemical examination of chorionic villi in early pregnancy showed that the activity of glycogen and alkaline phosphatase of the two layers of chorionic villi was very strong, which reflected the active metabolism. The activity of cytoplasmic acid phosphatase in the trophectoderm gradually increased from 60 days to 90 days, Trophoblast degradation related. 3β-HSD plays an important role in the steroid biosynthesis process, and 3β-HSD of trophoblast cells are all positive, indicating that they have the function of steroid biosynthesis. Implantation, early pregnancy process, villi, decidua is the mother - embryo direct contact and interrelated two organizations, from the family planning point of view, in the development of anti-implantation, anti-early pregnancy drug research work on the decidua, villus morphology and The study of function should pay attention to.