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透明质酸（ＨＡ）是细胞外间质（ＥＣＭ）的主要成分之一，参与组织重建、扩增细胞间隙、炎症反应和肿瘤发生等许多细胞生理、病理过程。研究表明ＨＡ的细胞效应是通过细胞表面ＨＡ结合蛋白与ＨＡ结合后发生的，粘附分子ＣＤ４４是ＨＡ的细胞表面受体，是一类分布极为广泛的细胞表面糖蛋白，它参与细胞一细胞之间以及细胞一基质之间的特异性粘连。在不同的细胞中，ＣＤ４４蛋白在表达水平，Ｖ区外显子的拼接及翻译后加工等方面均存在较大差异。研究结果表明，ＣＤ４４与ＨＡ的相互作用对胚胎细胞发育、免疫应答及肿瘤生长、转移具有重要作用。
Hyaluronic acid (HA) is one of the main components of the extracellular matrix (ECM) and participates in many physiological and pathological processes such as tissue remodeling, expansion of intercellular spaces, inflammation, and tumorigenesis. Studies have shown that the cellular effect of HA is caused by the binding of HA-binding protein on the cell surface to HA. Adhesion molecule CD44 is a cell surface receptor of HA. It is a very widely distributed cell surface glycoprotein, which is involved in the cell-cell Between and cell-matrix specific adhesions. In different cells, there were significant differences in the expression level of CD44 protein, the exons of V region exons, and post-translational processing. The results show that the interaction between CD44 and HA plays an important role in embryonic cell development, immune response and tumor growth and metastasis.