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目的 :测定鼻咽癌患者血清 β2 微球蛋白 (β2 MG)、纤维连接蛋白 (Fn)和白细胞介素 2 (IL 2 )的水平及意义。方法 :采用放射免疫检测技术、琼脂扩散法和酶联免疫吸附试验测量 32例鼻咽癌患者治疗前后血清 β2 MG、Fn和IL 2含量 ,并与对照组进行比较。结果 :鼻咽癌患者血清 β2 MG含量明显高于对照组 ,但Fn、IL 2含量却明显低于对照组 ,差异均有显著性意义 (P <0 .0 5 ) ;治疗后鼻咽癌患者血清 β2 MG含量明显下降 ,而Fn、IL 2含量显著升高 (P <0 .0 5 )。结论 :血清 β2 MG、Fn和IL 2含量的测定对鼻咽癌的诊断和预后评估有一定的意义。
Objective: To determine the serum level of β2 microglobulin (β2 MG), fibronectin (Fn) and interleukin 2 (IL 2) in patients with nasopharyngeal carcinoma and its significance. Methods: Serum β2 MG, Fn and IL2 levels in 32 NPC patients before and after treatment were measured by radioimmunoassay, agar diffusion and enzyme-linked immunosorbent assay (ELISA), and compared with the control group. Results: Serum β2-MG levels in patients with nasopharyngeal carcinoma were significantly higher than those in the control group, but the levels of Fn and IL-2 were significantly lower than those in the control group (P <0.05) Serum β2 MG content decreased significantly, while Fn, IL 2 levels were significantly increased (P <0.05). Conclusion: The determination of serum β2 MG, Fn and IL 2 levels has certain significance for the diagnosis and prognosis evaluation of nasopharyngeal carcinoma.