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目的观察米非司酮配伍米索前列醇(注射用水湿化)阴道置药的药物流产效果。方法将来蕉玲县计划生育服务站自愿行药物流产的早孕妇女345例随机分为观察组、对照Ⅰ组和对照Ⅱ组3组,每组各115例。3组均口服米非司酮,每次25 mg,每日3次,共2天。第3天观察组阴道放置米索前列醇并用注射用水湿化,对照Ⅰ组口服米索前列醇,对照Ⅱ组阴道直接放置米索前列醇。结果观察组、对照Ⅰ组和对照Ⅱ组完全流产率分别为96.52%、90.43%和89.57%,观察组与对照Ⅰ组比较差异无统计学意义(P>0.05),观察组与对照Ⅱ组比较差异有统计学意义(P<0.05)。胃肠道反应发生率观察组和对照Ⅱ组均较低,两组分别与对照Ⅰ组比较差异有统计学意义(P<0.05)。观察组、对照Ⅰ组和对照Ⅱ组孕囊排出时间分别为(3.13±1.10)h、(4.78±1.32)h和(4.90±1.42)h,观察组与对照组比较差异有统计学意义(P<0.05)。结论米非司酮配伍注射用水湿化米索前列醇阴道置药终止早孕效果好,不良反应少,值得临床推广应用。
Objective To observe the abortion effect of mifepristone combined with misoprostol (water for injection) to vaginal drug delivery. Methods In the future, 345 pregnant women with spontaneous medical abortion at Jiaonaling County Family Planning Service Station were randomly divided into observation group, control Ⅰ group and control Ⅱ group, with 115 cases in each group. 3 groups were oral mifepristone, 25 mg each time, 3 times a day, a total of 2 days. On the 3rd day, the misoprostol was placed vaginally in the observation group and wet with water for injection. The control group Ⅰ was given misoprostol orally, while the control group Ⅱ was placed misoprostol directly in the vagina. Results The complete abortion rate of the observation group, control group Ⅰ and control group Ⅱ were 96.52%, 90.43% and 89.57% respectively. There was no significant difference between the observation group and the control group Ⅰ (P> 0.05), the observation group and the control group Ⅱ The difference was statistically significant (P <0.05). The incidence of gastrointestinal reactions was lower in the observation group and the control group Ⅱ. There was significant difference between the two groups and the control group Ⅰ (P <0.05). The gestational sac excretion time of observation group, control Ⅰ group and control Ⅱ group were (3.13 ± 1.10) h, (4.78 ± 1.32) h and (4.90 ± 1.42) h, respectively. The difference between the observation group and the control group was statistically significant (P <0.05). Conclusion Mifepristone compatibility with water injection of misoprostol vaginal delivery of drugs to terminate early pregnancy effect, fewer adverse reactions, it is worth promoting the clinical application.