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With the antibiotic abuse and the resulting increased anti-biotic resistance,the bacterial infection has posed a se-rious threat to human health.Photodynamic therapy is an effective tool for treating localized and superficial infections.It is a promising approach for the treatment of superbugs and with minimal risk of induced antibiotic resistance.Herein,an isoquino-linium-based photosensitizer,LIQ-TPE,with aggregation-induced emission properties is designed and synthesized.It is with high 1O2 generation efficiency and shows efficient antibacterial performance towards both Gram-negative and Gram-positive bacteria,and even methicillin-resistant Staphylococcus oureus(MRSA).LIQ-TPE thus shows great promise as an effective antimicrobial agent to combat the menace of multi-drug resistant bacteria.