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目的探讨联合检测C反应蛋白(CRP)、D-二聚体和癌胚抗原(CEA)在诊断胸腔积液性质中的意义。方法收集76例恶性胸腔积液患者(试验组)和58例结核性胸腔积液患者(对照组)的胸腔积液标本,检测胸腔积液中CRP、D-二聚体和CEA的数值,并进行统计学分析。结果试验组D-二聚体和CEA的阳性率显著高于对照组,差异有统计学意义(P<0.05或P<0.01),而CRP含量却显著低于对照组,差异有统计学意义(P<0.01)。结论 CRP、D-二聚体和CEA的联合检测可提高对胸腔积液性质诊断的准确性。
Objective To explore the significance of combined detection of C-reactive protein (CRP), D-dimer and carcinoembryonic antigen (CEA) in the diagnosis of pleural effusion. Methods Pleural effusion specimens from 76 patients with malignant pleural effusion (experimental group) and 58 patients with tuberculous pleural effusion (control group) were collected to measure the values of CRP, D-dimer and CEA in pleural effusion Statistical analysis. Results The positive rate of D-dimer and CEA in the experimental group was significantly higher than that in the control group (P <0.05 or P <0.01), but the CRP content was significantly lower than that in the control group (P <0.05 or P <0.01) P <0.01). Conclusion The combined detection of CRP, D-dimer and CEA can improve the diagnostic accuracy of pleural effusion.