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目的分析临颍县近5年来涂阳肺结核病人的化疗效果,为提高治疗质量提供依据。方法采用含异烟肼、利福平、吡嗪酰胺、乙胺丁醇(HRZE)强化期和HRZ继续期2阶段全程间歇短程化疗方案和全程督导的管理方法。结果初治涂阳病人2、3个月末的痰菌阴转率分别为95.9%和97.1%,治愈率为91.6%;复治涂阳病人的2、3个月末的痰菌阴转率分别为91.3%和94.2%,治愈率为86.0%。结论2个阶段全程间歇的短程化疗方案具有疗效高、不良反应少、经济的优点,全程督导管理是有效的管理方法,值得推广使用。
Objective To analyze the chemotherapy effect of smear positive pulmonary tuberculosis patients in Linying County in the recent 5 years and provide the basis for improving the quality of treatment. Methods The management methods including isoniazid, rifampicin, pyrazinamide, ethambutol (HRZE) and HRZ continuous 2-cycle intermittent short-course chemotherapy and full supervision were used. Results The smear-negative conversion rates of smear-positive patients at the end of 2 and 3 months were 95.9% and 97.1% respectively, and the cure rate was 91.6%. The sputum negative conversion rates at the end of 2 and 3 months were 91.3% and 94.2%, the cure rate was 86.0%. Conclusions The short-course chemotherapy regimen with intermittent short-term chemotherapy in two stages has the advantages of high curative effect, less adverse reactions and economic advantages. It is an effective management method to supervise management and is worth promoting.