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妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)病因复杂,目前研究认为遗传因素在其发病机制中起着相当关键的作用。其中ABCC4基因与ICP的发病尤为密切。肝细胞以胆固醇为原料合成初级胆汁酸,7α-羟化酶催化这一反应的限
The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) is complicated. At present, studies suggest that genetic factors play a crucial role in its pathogenesis. The incidence of ABCC4 gene and ICP is particularly close. Primary hepatocytes synthesize primary bile acids from cholesterol and 7α-hydroxylase catalyzes this reaction