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目的比较研究尼美舒利（ＮＩＭ）和肠溶阿司匹林（ＡＳＰ）治疗牙科手术后疼痛的疗效和安全性。方法试验设计为随机单盲对照。试验组１２０例病例，于手术后疼痛时一次口服ＮＩＭ２００ｍｇ，过２４ｈ再口服２００ｍｇ；对照组６０例病例，于手术后疼痛时一次口服ＡＳＰ６００ｍｇ，过２４ｈ再口服６００ｍｇ。结果ＮＩＭ总有效率为９１６７％，ＡＳＰ总有效率为８６６７％。两药均能改善患者的症状和体征。经安全性评价，ＮＩＭ和ＡＳＰ的耐受性相近，不良反应以胃肠道反应为主。结论ＮＩＭ治疗牙科的疗效优于ＡＳＰ，在用药８ｈ内ＮＩＭ对症状和体征的改善优于ＡＳＰ，两药的耐受性无明显差异。
Objective To compare the efficacy and safety of nimesulide (NIM) and enteric-coated aspirin (ASP) in the treatment of pain after dental surgery. Methods The experimental design was randomized single-blind control. In the trial group, 120 cases were treated with NIM200mg orally once after surgery and 200mg orally after 24 hours. In the control group, 60 cases were treated with ASP600mg orally once after the operation and over 600mg orally after 24h. Results The total effective rate of NIM was 9167% and the total effective rate of ASP was 8667%. Both drugs can improve the patient’s symptoms and signs. After the safety evaluation, NIM and ASP are similar in tolerability, with the main gastrointestinal reactions. Conclusion The efficacy of NIM in the treatment of dental diseases is better than that of ASP. The improvement of symptoms and signs of NIM is better than that of ASP within 8h. There is no significant difference between the two drugs in tolerability.