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目的探讨固尔苏联合鼻塞式气道正压通气治疗新生儿呼吸窘迫综合征的疗效及对患者炎症因子的影响。方法选取2012年1月~2014年12月在该院就诊的新生儿呼吸窘迫综合征患者106例为研究对象,随机分成对照组和观察组,每组各53例。对照组接受常规治疗同时应用鼻塞式气道正压通气治疗,观察组接受常规治疗同时应用固尔苏联合鼻塞式气道正压通气治疗。结果观察组总有效率(92.45%)高于对照组(77.36%),差异有统计学意义(P<0.05)。治疗后,观察组患者Pa CO2水平低于对照组,Pa O2水平高于对照组,差异均有统计学意义(P均<0.05)。治疗8、24、48、72 h后,观察组患者TNF-α、SF水平均低于对照组,IL-10水平均高于对照组,差异均有统计学意义(P<0.05)。观察组患者的呼吸机相关性肺炎、颅脑出血、肺出血以及动脉导管未闭并发症的发生率与对照组比较,差异均无统计学意义(P>0.05)。结论固尔苏联合鼻塞式气道正压通气治疗新生儿呼吸窘迫综合征疗效显著,能够有效改善血气指标、减轻患者的炎症反应。
Objective To investigate the curative effect of gastrose combined with nasal endoscopic positive pressure ventilation on neonatal respiratory distress syndrome and its effect on inflammatory factors. Methods A total of 106 neonatal respiratory distress syndrome patients treated in our hospital from January 2012 to December 2014 were selected as study subjects and randomly divided into control group and observation group with 53 cases in each group. The control group received routine treatment while applying nasal airway pressure positive airway pressure treatment. The observation group received routine treatment while applying Curelou combined with nasal airway pressure positive airway pressure treatment. Results The total effective rate (92.45%) in observation group was higher than that in control group (77.36%), the difference was statistically significant (P <0.05). After treatment, the PaCO 2 level in the observation group was lower than that in the control group, Pa O 2 level was higher than that in the control group (all P <0.05). After 8, 24, 48 and 72 h of treatment, the levels of TNF-α and SF in the observation group were lower than those in the control group, and the levels of IL-10 in the observation group were significantly higher than those in the control group (P <0.05). The incidence of ventilator-associated pneumonia, cerebral hemorrhage, pulmonary hemorrhage and patent ductus arteriosus complication in the observation group was not significantly different from the control group (P> 0.05). Conclusion Gasol combined with nasal endoscopic positive airway pressure in the treatment of neonatal respiratory distress syndrome has a significant effect, which can effectively improve the blood gas index and reduce the patient’s inflammatory response.